Mick Newell's table-toppers have won their last four games in the Frizzell County Championship and are gunning for a fifth consecutive victory for the first time since 1925.
Back then, the Notts attack included a raw, 20-year-old fast bowler called Harold Larwood while the batting was opened by the county's most prolific run-scorer, George Gunn.
Star of the current winning run is leading wicket-taker Paul Franks and no-one is more desperate to match the historic landmark.
He said: "Games against Derbyshire come with plenty of local rivalry built in and having a 79-year-old record at stake gives us even more incentive to continue making a strong play for the top of the table.
"Any landmarks we set along the way will be very nice for the team to look back on and with confidence sky high, we know that by playing as well as we have been we can beat Derbyshire to make it five."
Apart from the stunning Notts run, other notable events in 1925 were the first trials of television by John Logie-Baird and the birth of Margaret Thatcher.
Added Director of Cricket Mick Newell: "It's surprising it's been so long but to win five on the trot is some task and it would be great to achieve that feat against our arch-rivals.
"Derbyshire's always a game we look forward to at Trent Bridge because we know they want to come here and try to shoot us down.
"It'll be a tense encounter as always and even though there may not be too many locals on either side, you can guarantee there will still be plenty of feeling on the pitch."
The four-day game runs until Monday and entry is ?10 per day for adults or ?5 for juniors under 16 and OAPs.
THURSDAY 21 SEPTEMBER 2017
ENGLAND v WEST INDIES