Andre Adams will return from his limited overs lay-off to lead the line against Lancashire.
The influential bowler has been a talismanic figure in Nottinghamshire's surge to the top of the LV= County Championship and he is set to remain sidelined from limited overs cricket to maximise his prowess.
Ben Phillips and Luke Fletcher are both out through injury although Fletcher is expected to make his return soon having bowled in the nets since recovering from knee trouble.
Paul Franks and Harry Gurney come into the side with Andy Carter keeping his place whilst the batting line-up is unchanged as Nottinghamshire look to build on an emphatic win against Sussex at Hove in their previous four-day outing.
Riki Wessels and Alex Hales will open the batting with Michael Lumb, Samit Patel, James Taylor, Adam Voges and Chris Read completing a formidable top seven.
Nottinghamshire team to face Lancashire: Riki Wessels, Alex Hales, Michael Lumb, Samit Patel, James Taylor, Adam Voges, Chris Read, Paul Franks, Andre Adams, Harry Gurney, Andy Carter