Billy Root top-scored for Nottinghamshire with 66, but it was Leicestershire that took control on day two of the Second XI Championship fixture at Lady Bay.
Tom Moores scored 34, but nobody else passed 20, as the hosts were all out for 165 in reply to the visitors’ 328 all out.
Left-arm spinner Callum Parkinson, a close season signing from Derbyshire, took four wickets for eight runs. Former Worcestershire paceman Richard Jones ended with figures of 3-36.
The lead had been extended to 334 by the close; Matt Milnes, Ben Kitt and Matt Carter sharing the wickets as Leicestershire reached 171-4.
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